There is 1 game documented on PixelatedArcade supporting Lo-Res.
Lo-Res is part of the category Display Hardware Supported.
Lo-Res graphics on the Apple II series of computers could display 16 colors at a time with a resolution of 40x48 graphics or 40x40 graphics with 4 rows of text at the bottom of the screen. By default this display mode would be initialized with 40x40 graphics and text.